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The alcohol dehydrogenase system becomes saturated with very small amounts of ethanol

Therefore, a combination of transcellular and paracellular routes for crossing the nasopharyngeal barrier is also possible if the meningococci crossing via the transcellular route induce a sufficient level of inflammation to alter epithelial permeability, allowing other bacteria to follow the paracellular route

Effect of palmitoylethanolamide on inner retinal function in glaucoma: a randomized, single blind, crossover, clinical trial by pattern-electroretinogram

While genetic variation in TSD susceptibility has been reported in reptiles and amphibians (e.g., laboratory studies have shown genetic variation in specific populations), whether this variation provides sufficient adaptive capacity remains an open question (Urban et al., 2013)